GOING ABOVE AND BEYOND
CONSULTATION ON STUDY DESIGN, DATA INTERPRETATION, COMPOUND SELECTION AND OPTIMIZATION
In Vitro ADME
Caco-2 Permeability
- Metabolic Stability
- CYP450 Inhibition
- CYP450 Induction
- CYP450 Phenotyping
- UGT Inhibition
- UGT Phenotyping
- Uptake Transporter Inhibition
- Uptake Transporter Phenotyping
- Efflux Transporter Inhibition
- Efflux Transporter Phenotyping
- Additional Drug-Metabolizing Enzyme Phenotyping (FMOs, MAOs, AOs, ALDH, ADH)
- Plasma or Whole Blood Stability
- Blood-to-Plasma Partitioning
- Plasma Protein Binding
- Tissue Binding
- Drug Metabolite Profiling and Structural Identification